haplotype analysis of hemochromatosis gene polymorphisms in chronic hepatitis c virus infection: a case control study

Authors

sina gerayli department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, ir iran; department of biology, western university, london, ontario, n6a 5b7, canada

alireza pasdar department of modern sciences and technologies, faculty of medicine, mashhad university of medical sciences, mashhad, ir iran; division of applied medicine, medical school, university of aberdeen, foresterhill, aberdeen, ab25 2zd, uk

mohammad taghi shakeri department of biostatistics, public health school, mashhad university of medical sciences, mashhad, ir iran

samaneh sepahi targeted drug delivery research center, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran

abstract

conclusions polymorphism in the hemochromatosis gene may confer some degree of risk for hcv infection, and individuals carrying the h and c alleles may be susceptible to this disease; however, a larger sample of hcv patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in hcv. patients and methods hfe gene polymorphisms were examined in a total of 69 hcv patients and 69 healthy controls using polymerase chain reaction and restriction fragment length polymorphism techniques. haplotype and diplotype analyses were performed using phase software. results in a recessive analysis model of the his63asp (h63d) locus (hh vs. hd + dd), the hh genotype was more common in patients compared to controls (adjusted p = 0.012; or = 6.42 [95% ci: 1.51 - 27.33]). also, in a recessive analysis model of the cys282tyr (c282y) locus (cc vs. cy + yy), the cc genotype was more frequent in patients compared to controls (adjusted p = 0.03; or = 5.06 [95% ci: 1.13 - 22.06]). in addition, there was a significant association between the hc haplotype and the hcdc diplotype and hcv infection. background chronic hepatitis c virus (hcv) infection is frequently associated with elevated serum iron markers. polymorphisms in the hemochromatosis (hfe) genes are responsible for iron accumulation in most cases of hemochromatosis, and may play a role in hcv infection. objectives we aimed to assess the prevalence of hfe gene polymorphisms in a group of iranian hcv-infected patients, and to explore the association of these polymorphisms with hcv infection.

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Journal title:
iranian red crescent medical journal

جلد ۱۸، شماره ۶، صفحات ۰-۰

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